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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-4
All Species:
24.24
Human Site:
S215
Identified Species:
44.44
UniProt:
Q9H2Z4
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H2Z4
NP_149416.1
354
36179
S215
F
K
Q
Q
K
Y
L
S
A
P
E
R
E
H
L
Chimpanzee
Pan troglodytes
XP_525278
419
42955
S280
F
K
Q
Q
K
Y
L
S
A
P
E
R
E
H
L
Rhesus Macaque
Macaca mulatta
XP_001093634
451
46942
S312
F
K
Q
Q
K
Y
L
S
A
P
E
R
E
H
L
Dog
Lupus familis
XP_849082
233
24205
K121
Q
N
H
R
Y
K
M
K
R
Q
A
K
D
K
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQM3
354
36207
S214
F
K
Q
Q
K
Y
L
S
A
P
E
R
E
H
L
Rat
Rattus norvegicus
P23441
372
38536
L200
H
L
A
S
M
I
H
L
T
P
T
Q
V
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
T182
K
R
Q
R
Q
D
Q
T
L
E
M
V
G
I
P
Frog
Xenopus laevis
P42587
196
22791
L84
S
K
A
Q
T
Y
E
L
E
R
R
F
R
Q
Q
Zebra Danio
Brachydanio rerio
Q90481
269
30288
E156
Y
L
S
A
P
E
R
E
H
L
A
S
L
I
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22808
723
76404
S571
F
R
Q
Q
R
Y
L
S
A
P
E
R
E
H
L
Honey Bee
Apis mellifera
XP_394578
395
41030
S238
F
K
Q
Q
K
Y
L
S
A
P
E
R
E
H
L
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
I187
R
E
Q
L
A
N
S
I
R
L
T
P
T
Q
V
Sea Urchin
Strong. purpuratus
NP_999800
411
44821
K252
V
A
V
P
V
L
V
K
D
G
K
P
C
N
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
84.2
77.1
61.2
N.A.
94.3
59.4
N.A.
N.A.
29.9
28.8
31
N.A.
24.3
37.9
31.6
38.9
Protein Similarity:
100
84.2
77.1
62.9
N.A.
94.6
66.4
N.A.
N.A.
42
38.4
42.9
N.A.
32
49.6
43.7
51.3
P-Site Identity:
100
100
100
0
N.A.
100
6.6
N.A.
N.A.
6.6
20
0
N.A.
86.6
100
6.6
0
P-Site Similarity:
100
100
100
26.6
N.A.
100
20
N.A.
N.A.
33.3
20
6.6
N.A.
100
100
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
16
8
8
0
0
0
47
0
16
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
0
0
0
0
8
0
0
8
0
0
0
8
0
0
% D
% Glu:
0
8
0
0
0
8
8
8
8
8
47
0
47
0
0
% E
% Phe:
47
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
8
% G
% His:
8
0
8
0
0
0
8
0
8
0
0
0
0
47
0
% H
% Ile:
0
0
0
0
0
8
0
8
0
0
0
0
0
16
8
% I
% Lys:
8
47
0
0
39
8
0
16
0
0
8
8
0
16
0
% K
% Leu:
0
16
0
8
0
8
47
16
8
16
0
0
8
0
47
% L
% Met:
0
0
0
0
8
0
8
0
0
0
8
0
0
0
0
% M
% Asn:
0
8
0
0
0
8
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
8
8
0
0
0
0
54
0
16
0
0
8
% P
% Gln:
8
0
62
54
8
0
8
0
0
8
0
8
0
16
8
% Q
% Arg:
8
16
0
16
8
0
8
0
16
8
8
47
8
0
8
% R
% Ser:
8
0
8
8
0
0
8
47
0
0
0
8
0
0
0
% S
% Thr:
0
0
0
0
8
0
0
8
8
0
16
0
8
0
0
% T
% Val:
8
0
8
0
8
0
8
0
0
0
0
8
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
8
54
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _